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Our Latest Publications

Augustin G, Bhinderwala F, Alexander ND, Hernández I, Stanisheuski S, Monnie CM, Eddins AJ, Gangarde YM, Soloshonok VA, Oiarbide M, Landa A, Cooley RB, Gronenborn AM, Mehl RA. Endogenous Site-Specific Encoding of Trifluoromethyl-Bearing Phenylalanine and Tryptophan for in-Cell 19F NMR. J Am Chem Soc. 2026

Alexander ND, Gangarde YM, Bednar RM, Karplus PA, Cooley RB, Mehl RA. Selecting aminoacyl-tRNA synthetase/tRNA pairs for efficient genetic encoding of noncanonical amino acids into proteins. Nat Protoc. 2025

Jana S, Eddins AJ, Gangarde YM, Karplus PA, Mehl RA. Tuning Encodable Tetrazine Chemistry for Site-Specific Protein Bioorthogonal Ligations. Angew Chem Int Ed Engl. 2025

Eddins AJ, Gangarde YM, Singh A, Jana S, Zheng Y, Alexander ND, Reitsma JM, Cooley RB, Karplus PA, Mehl RA. Quantitative Protein Labeling in Live Cells by Controlling the Redox State of Encoded Tetrazines. J Am Chem Soc. 2025

Zheng Y, Singh A, Niu Z, Marin V, Young J, Richardson P, Hemshorn ML, Cooley RB, Karplus PA, Puvar K, Warder SE, Vasudevan A, Reitsma JM, Mehl RA. In-Cell Approach to Evaluate E3 Ligases for Use in Targeted Protein Degradation. J Am Chem Soc. 2025

Eddins AJ, Pung AH, Cooley RB, Mehl RA. Tetrazine Amino Acid Encoding for Rapid and Complete Protein Bioconjugation. Bio Protoc. (2024).

Allen MC, Karplus PA, Mehl RA, Cooley RB. Genetic Encoding of Phosphorylated Amino Acids into Proteins. Chem Rev. (2024)

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Publications from our Driving Biomedical Partners

Saleh IG, Shimogawa M, Ramirez J, Abakah B, Venkatesh Y, James HP, Li MH, Louie SA, Lougee MG, Chia WK, Brue C, Cooley RB, Mehl RA, Baumgart T, Mach RH, Eliezer D, Rhoades E, Petersson EJ. Genetic code expansion and enzymatic modifications as accessible methods for studying site-specific post-translational modifications of alpha-synuclein and tau. Protein Sci. 2025

Boeszoermenyi A, Radeva DL, Schindler S, Valadares V, Padmanabha Das KM, Dubey A, Viennet T, Schmitt M, Kast P, Gelev VM, Stoyanov N, Burdzhiev N, Petrov O, Ficarro S, Marto J, Geffken EA, Dhe-Paganon S, Seo HS, Alexander ND, Cooley RB, Mehl RA, Kovacs H, Anklin C, Bermel W, Kuprov I, Takeuchi K, Arthanari H. Leveraging relaxation-optimized ¹H-¹³C_F correlations in 4-¹⁹F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins. Nat Chem. 2025

Koh DS, Stratiievska A, Jana S, Otto SC, Swanson TM, Nhim A, Carlson S, Raza M, Naves LA, Senning EN, Mehl RA, Gordon SE. Genetic code expansion, click chemistry, and light-activated PI3K reveal details of membrane protein trafficking downstream of receptor tyrosine kinases. Elife. 2024

Chadda R, Kaushik V, Ahmad IM, Deveryshetty J, Holehouse AS, Sigurdsson ST, Biswas G, Levy Y, Bothner B, Cooley RB, Mehl RA, Dastvan R, Origanti S, Antony E. Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation. Nucleic Acids Res. 2024

Galles GD, Infield DT, Clark CJ, Hemshorn ML, Manikandan S, Fazan F, Rasouli A, Tajkhorshid E, Galpin JD, Cooley RB, Mehl RA, Ahern CA. Tuning phenylalanine fluorination to assess aromatic contributions to protein function and stability in cells. Nat Commun. 2023