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In the News
College of Science IMPACT Magazine -
Oregon State opens the world's first-ever Genetic Code Expansion Center
Latest GCE research publications
Eddins AJ, Bednar RM, Jana S, Pung AH, Mbengi L, Meyer K, Perona JJ, Cooley RB, Karplus PA, Mehl RA. Truncation-Free Genetic Code Expansion with Tetrazine Amino Acids for Quantitative Protein Ligations. (2023). Bioconjug Chem.
Jana S, Evans EGB, Jang HS, Zhang S, Zhang H, Rajca A, Gordon SE, Zagotta WN, Stoll S, Mehl RA. Ultra-Fast Bioorthogonal Spin-Labeling and Distance Measurements in Mammalian Cells Using Small, Genetically Encoded Tetrazine Amino Acids. (2023). J Am Chem Soc.
Zhu P, Stanisheuski S, Franklin R, Vogel A, Vesely CH, Reardon P, Sluchanko NN, Beckman JS, Karplus PA, Mehl RA, Cooley RB. Autonomous Synthesis of Functional, Permanently Phosphorylated Proteins for Defining the Interactome of Monomeric 14-3-3. (2023). ACS Cent Sci.
Bednar RM, Karplus PA, and Mehl RA. Site-specific dual encoding and labeling of proteins via genetic code expansion. (2023). Cell Chem Bio.
Zhu P, Nguyen KT, Estelle AB, Sluchanko NN, Mehl RA, Cooley RB. Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation. (2023). Protein Science.
Galles GD, Infield DT, Clark CJ, Hemshorn ML, Manikandan S, Fazan F, Rasouli A, Tajkhorshid E, Galpin JD, Cooley RB, Mehl RA. Tuning phenylalanine fluorination to assess aromatic contributions to protein function and stability in cells. (2023). Nature Communications.
Buchko GW, Zhou M, Hoang Vesely C, Tao J, Shaw WJ, Mehl RA, Cooley RB. High-yield recombinant bacterial expression of 13C-, 15N-labeled, serine-16 phosphorylated, murine amelogenin using a modified third generation genetic code expansion protocol. (2023). Protein Science.
Gottfried-Lee I, Perona JJ, Karplus PA, Mehl RA, Cooley RB. Structures of Methanomethylophilus alvus Pyrrolysine tRNA-Synthetases Support the Need for De Novo Selections When Altering the Substrate Specificity. (2022). ACS Chem Biol.
Avila-Crump S, Hemshorn ML, Jones CM, Mbengi L, Meyer K, Griffis JA, Jana S, Petrina GE, Pagar VV, Karplus PA, Petersson EJ, Perona JJ, Mehl RA, Cooley RB. Generating Efficient Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetases for Structurally Diverse Non-Canonical Amino Acids. (2022). ACS Chem Biol.
Hoang Vesely C, Reardon PN, Zhen Y, Barbar E, Mehl RA, Cooley RB. Accessing isotopically labeled proteins containing genetically encoded phosphoserine for NMR with optimized expression conditions. (2022). JBC.